This article explains the role of blood sample cards in DNA database construction, highlighting their value in standardized, long-term genetic sample storage and processing.
Core Roles
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Sample Stabilization: Absorb and preserve blood-derived DNA at room temp for 5+ years, eliminating cold storage needs during database sample collection.
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Standardized Sampling: Uniform blood absorption capacity (50–100μL) ensures consistent DNA yield, critical for database profile uniformity.
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Easy Archiving: Compact, dry format saves storage space, enabling efficient cataloging of thousands of samples in database repositories.
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Traceability Link: Integral labeling panels (sample ID, donor info) connect physical samples to digital database records for chain of custody.
Key Features
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FTA Technology: Specialized matrix inhibits microbial growth and DNA degradation, maintaining sample quality.
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Minimal Processing: Direct DNA extraction from card punches simplifies lab workflow for database profiling.
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Cost-Effective: Lower storage/transport costs vs. liquid blood samples, supporting large-scale database expansion.
Application Scope
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Forensic Databases: Storing offender/victim blood samples for criminal identity matching (e.g., CODIS).
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Population Genetics Databases: Collecting blood samples for ancestry, disease prevalence, and genetic diversity studies.
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Biobank Databases: Archiving blood-derived DNA for long-term research and clinical reference.